- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
GRO alpha antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
GRO alpha Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells, mouse small intestine tissue. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 8 kDa
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
C X C motif chemokine 1, CXCL1, FSP, GRO, GRO alpha(1 73), GRO1, GROa, Growth regulated alpha protein, MGSA, MGSA a, NAP 3, SCYB1
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制备方法
This antibody was obtained by immunization of GRO alpha recombinant protein (Accession Number: NM_001511). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
CXCL1, also named as FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3 and SCYB1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene. It has chemotactic activity for neutrophils. CXCL1 may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis.This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.
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参考文献
- Peng W, Ye Y, Rabinovich BA. Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses. Clinical cancer research : an official journal of the American Association for Cancer Research. 16(22):5458-68. 2010.
- Sapoznik S, Ortenberg R, Galore-Haskel G. CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy. Cancer immunology, immunotherapy : CII. 61(10):1833-47. 2012.
- Jiao Y, Darzi Y, Tawaratsumida K. Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. Cell host & microbe. 13(5):595-601. 2013.
- Erez N, Glanz S, Raz Y, Avivi C, Barshack I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochemical and biophysical research communications. 437(3):397-402. 2013.
- Wu T, Du R, Hong Y, Jia L, Zeng Q, Cheng B. IL-1 alpha regulates CXCL1, CXCL10 and ICAM1 in network form in oral keratinocytes. Clinical laboratory. 59(9-10):1105-11. 2013.
- Grgic I, Hofmeister AF, Genovese G. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney international. 86(6):1116-29. 2014.
- Cao Z, Fu B, Deng B, Zeng Y, Wan X, Qu L. Overexpression of Chemokine (C-X-C) ligand 1 (CXCL1) associated with tumor progression and poor prognosis in hepatocellular carcinoma. Cancer cell international. 14(1):86. 2014.
- Yeh CY, Shun CT, Kuo YM. Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis. Infection and immunity. 83(6):2202-12. 2015.