重组人ALDOB蛋白

人

大肠杆菌

Ala 2 - Tyr 364

A DNA sequence encoding the human ALDOB (P05062) (Ala 2-Tyr 364) was fused with the GST tag at the N-terminus.

> 88 % as determined by SDS-PAGE

The recombinant human ALDOB/GST chimera consists of 597 amino acids and has a predicted molecular mass of 66.5 kDa. It migrates as an approxiamtely 60 KDa band in SDS-PAGE under reducing conditions.

ALDO2; FRUCTOSE-BISPHOSPHATE ALDOLASE B; FRUCTOSE-BISPHOSPHATASE; ALDOLASE B; LIVER-TYPE ALDOLASE; BC016435; ALDOLASE 2; ALDB; RP11-490D19.1; ALDO-2

Fructose-bisphosphate aldolase B

Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.

Lyophilized from sterile PBS, pH 7.5
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
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Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.