- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
Frizzled 10 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Frizzled 10 Rabbit Polyclonal antibody. Positive WB detected in mouse kidney tissue, HeLa cells. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 65 kDa
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
CD350, Frizzled 10, FZ 10, FZD10, FzE7, hFz10
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制备方法
This antibody was obtained by immunization of Frizzled 10 recombinant protein (Accession Number: NM_007197). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
FZD10 (Frizzled homolog 10) is a member of the frizzled gene family, and considered as a seven-transmembrane Wnt-signaling receptor. FZD10 is expressed at high levels on the cell surface of almost all synovial sarcoma tissues but absent in most normal organs except for placenta. Up-regulation of FZD10 mRNA in several types of human cells might lead to carcinogenesis through activation of the beta-catenin-TCF signaling pathway with some class of WNTs.
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参考文献
- Caron A, Xu X, Lin X. Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development (Cambridge, England). 139(3):514-24. 2012.
- Sun Q, Wang R, Luo J. Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway. International journal of oncology. 45(4):1638-48. 2014.