- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
Fibulin 5 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Fibulin 5 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue, human heart tissue, human pancreas tissue. Positive IP detected in mouse heart tissue. Positive WB detected in mouse heart tissue, mouse placenta tissue, rat brain tissue. Observed molecular weight by Western-blot: 64-66 kDa
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抗体应用
ELISA, WB, IHC, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
ARMD3, DANCE, EVEC, FBLN5, FIBL 5, fibulin 5, FLJ90059, UP50, Urine p50 protein
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制备方法
This antibody was obtained by immunization of Fibulin 5 recombinant protein (Accession Number: NM_006329). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Fibulin-5, also known as EVEC and DANCE, is a extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies. This antibody got 50kd or 66kd band in western blotting, the 66kd corresponding to fully glycosylated protein.
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参考文献
- Chen JY, Tsai PJ, Tai HC. Increased aortic stiffness and attenuated lysyl oxidase activity in obesity. Arteriosclerosis, thrombosis, and vascular biology. 33(4):839-46. 2013.
- Han W, Guo C, Liu Q. Aberrant elastin remodeling in the lungs of O₂-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin. Cell and tissue research. 359(2):589-603. 2015.