重组小鼠Fdps蛋白

小鼠

大肠杆菌

Met 1 - Lys 353

A DNA sequence encoding the mouse Fdps (NP_608219.1) (Met1-Lys353) was expressed with a polyhistidine tag at the N-terminus.

> 85 % as determined by SDS-PAGE.

The recombinant mouse Fdps consists 371 amino acids and predicts a molecular mass of 42.8 kDa.

AI256750; GERANYLTRANSTRANSFERASE; FPPS; FPP SYNTHETASE; MKIAA1293; FPP SYNTHASE; FARNESYL PYROPHOSPHATE SYNTHASE; FARNESYL PYROPHOSPHATE SYNTHETASE; 6E)-FARNESYL DIPHOSPHATE SYNTHASE; DIMETHYLALLYLTRANSTRANSFERASE; 6030492I17RIK; FDPSL1; FPS

Fdps protein

Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.

Lyophilized from sterile 50 mM Tris, pH 8.0.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

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Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.