- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human, Mouse, Rat; other species not tested.
产品详情
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产品名称
ERO1LB antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
ERO1LB Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse brain tissue, rat brain tissue. Positive IHC detected in human pancreas tissue. Observed molecular weight by Western-blot: 54kd
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human, Mouse, Rat; other species not tested.
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蛋白别名
ERO1 L beta, ERO1 like beta (S. cerevisiae), ERO1 like protein beta, ERO1LB, Oxidoreductin 1 L beta
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: NM_019891). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ERO1LB is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. It is required for the folding of cell, thereby being a source of oxidative stress. This antibody has no cross reaction to ERO1L.