Mertansine (DM1) Monoclonal Antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:ELISA
  • 特异性:Chemical

产品详情

  • 产品名称
    Mertansine (DM1) Monoclonal Antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Mouse IgG2b, κ
  • 抗体描述
    Product has been tested in direct ELISA.
  • 抗体应用
    ELISA
  • 应用推荐
    ELISA: 1:5,000-1:20,000
  • 特异性
    Chemical
  • 制备方法
    DM1 conjugated with BSA, Protein G affinity purified
  • 组分
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Mertansine, also called DM1 or Maytansinoid DM1, is a microtubulin inhibitor and it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site). Derivatives of maytansine are known as maytansinoids(e.g.: Mertansine(DM1), Ravtansine(DM4)). Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
  • 参考文献
    • Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, Jordan MA. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99. doi: 10.1158/1535-7163.MCT-10-0644. PMID: 20937594; PMCID: PMC2954514.
    • Zhong P, Qiu M, Zhang J, Sun H, Cheng R, Deng C, Meng F, Zhong Z. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28(29):295103. doi: 10.1088/1361-6528/aa76cc. Epub 2017 Jun 2. PMID: 28574851.
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