Recombinant Human DNA Fragmentation Factor Subunit Beta (DFFB) Fragment (1-338) – a high-purity protein encompassing the full CIDE-N domain, designed for studying apoptosis-related DNA fragmentation and chromatin condensation mechanisms.

DNA Fragmentation Factor Subunit Beta (DFFB), also known as Caspase-Activated DNase (CAD), is a nuclease critical for inducing DNA fragmentation and chromatin condensation during apoptosis. It degrades naked DNA and drives the morphological changes characteristic of programmed cell death. The protein is localized in both the cytoplasm and nucleus, facilitating its role in nuclear DNA breakdown upon activation. This recombinant fragment provides researchers with a targeted tool to investigate the specific functions of the CIDE-N domain in apoptotic pathways.