This product is a recombinant fragment of DDB1- and CUL4-associated factor 5 (also known as Breakpoint cluster region protein 2, BCRP2, or WD repeat-containing protein 22), encompassing amino acids 1-426. This stable and soluble fragment is ideal for structural studies and biochemical assays, offering researchers a reliable tool to investigate the protein's role in ubiquitination pathways.

DDB1- and CUL4-associated factor 5 (DCAF5) is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4). The CRL4-DCAF5 complex plays a critical role in the ubiquitination of methylated non-histone proteins, including key regulators such as SOX2, DNMT1, and E2F1. This function highlights its importance in cellular processes like gene expression regulation, DNA methylation maintenance, and cell cycle control, making it a significant target for research in molecular biology and disease mechanisms.