Recombinant Cell Surface Receptor DAF-4 Fragment (residues 87-199) from Caenorhabditis elegans, engineered as a stable and soluble unit ideal for structural biology and biochemical studies of TGF-beta signaling pathways.

The full-length DAF-4 protein is a single-pass type I membrane receptor localized to the cell membrane and plays a critical role in TGF-beta signaling pathways in C. elegans. It functions as a potential receptor for the TGF-beta-like ligand DAF-7, regulating key developmental processes including the dauer larval entry decision in response to environmental cues, body size determination, male tail patterning, entry into quiescence following satiety, and sensitivity to CO2 levels. This fragment represents a computationally optimized region selected for enhanced solubility and stability, facilitating experimental investigations into receptor function and interactions.