重组人CRIP2蛋白

产品详情

  • 产品名称
    重组人CRIP2蛋白
  • 蛋白种属
    人
  • 表达宿主
    杆状病毒 - 昆虫细胞
  • Unitprot ID
    P52943
  • 克隆构建
    A DNA sequence encoding the human CRIP2 (P52943) (Met1-Pro208) was expressed and purified.
  • 蛋白纯度
    > 95 % as determined by SDS-PAGE
  • 分子量
    The recombinant human CRIP2 consists of 210 amino acids and predicts a molecular mass of 22.6 KDa. It migrates as an approximately 26 KDa band in SDS-PAGE under reducing conditions.
  • 蛋白别名
    AW743261; 0610010I23RIK; LIM DOMAIN PROTEIN ESP1/CRP2; CRP2; ESP1; CRP4; LIM ONLY PROTEIN HLP; CYSTEINE-RICH INTESTINAL PROTEIN; C77570; HLP; CRIP2; CYSTEINE-RICH PROTEIN 2; CRIP; CRP; CRP-2; HEART LIM PROTEIN; CYSTEINE RICH PROTEIN 2
  • 蛋白全名
    Cysteine-rich protein 2
  • 蛋白描述
    CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-?B/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-?B-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.
  • 发货形式
    Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 7.4.
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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