- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IF
- 特异性:Human, Mouse, Rat; other species not tested.
产品详情
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产品名称
CSPP1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
CSPP1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HEK-293 cells, HeLa cells, mouse testis tissue, rat testis tissue. Positive IF detected in Hela cells. Observed molecular weight by Western-blot: 141kd
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抗体应用
ELISA, WB, IF
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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特异性
Human, Mouse, Rat; other species not tested.
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蛋白别名
CSPP, CSPP1, FLJ22490, FLJ38886
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制备方法
This antibody was obtained by immunization of CSPP1 recombinant protein (Accession Number: BC029445). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
CSPP1 interacts with centrosomes and microtubules and plays a role in cell-cycle progression and spindle organization. CSPP1 is required for their common C-terminal domain to interact with Nephrocystin 8 (NPHP8/RPGRIP1L) and to form a ternary complex with NPHP8 and NPHP4, and for ciliogenesis in hTERT-RPE1 cells in vitro and are expressed in ciliated renal, retinal, and respiratory cells in vivo
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参考文献
- Sternemalm J, Russnes HG, Zhao X. Nuclear CSPP1 expression defined subtypes of basal-like breast cancer. British journal of cancer. 111(2):326-38. 2014.
- Sternemalm J, Geimer S, Frikstad KA, Schink KO, Stokke T, Patzke S. CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation. PloS one. 10(8):e0134789. 2015.
- Patzke S, Redick S, Warsame A. CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. Molecular biology of the cell. 21(15):2555-67. 2010.
- Tuz K, Bachmann-Gagescu R, O'Day DR. Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy. American journal of human genetics. 94(1):62-72. 2014.
- Akizu N, Silhavy JL, Rosti RO. Mutations in CSPP1 lead to classical Joubert syndrome. American journal of human genetics. 94(1):80-6. 2014.