Introducing the recombinant fragment of Cell Cycle Progression Protein 1 (CCPG1), encompassing residues 276-457. This 182-amino acid fragment has been carefully selected for its stability and solubility, making it an ideal tool for structural studies, biochemical assays, and functional investigations into Rho protein signaling and cell cycle regulation.

Cell Cycle Progression Protein 1 (CCPG1) is a human protein that serves as an assembly platform for Rho protein signaling complexes. It specifically limits the guanine nucleotide exchange activity of MCF2L toward RHOA, thereby inhibiting both transcriptional activation and transforming activity. While it does not affect MCF2L activity toward CDC42 or MCF2 activity toward RHOA or CDC42, CCPG1 is believed to play a role in cell cycle regulation. The protein is localized to cytoplasmic granule membranes as a single-pass type II membrane protein, positioning it strategically for intracellular signaling functions.