Caspase 8 Polyclonal Antibody

0 条评论 | 添加你的评论
  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:WB, IHC, IF
  • 特异性:Human, Mouse, Rat

产品详情

  • 产品名称
    Caspase 8 Polyclonal Antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Polyclonal antibody to Caspase 8
  • 抗体应用
    WB, IHC, IF
  • 应用推荐
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
  • 特异性
    Human, Mouse, Rat
  • 蛋白别名
    CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase-8
  • 制备方法
    Antigen: Recombinant protein of mouse Caspase 8
  • 组分
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！