Recombinant BMAL1 (242-443) Fragment: A high-purity, functional protein fragment encompassing the PAS 2 domain of the human Basic helix-loop-helix ARNT-like protein 1 (BMAL1). This product is an essential tool for investigating circadian clock mechanisms, transcriptional regulation, and domain-specific interactions in circadian biology research.

BMAL1 is a core transcriptional activator of the circadian clock, forming heterodimers with CLOCK or NPAS2 to drive rhythmic gene expression by binding E-box promoter elements. It regulates diverse physiological processes, including metabolism, immune function, neurogenesis, and hormone signaling, through the transcription/translation feedback loop. The full-length protein localizes to the nucleus and cytoplasm, with nucleocytoplasmic shuttling critical for its function. This recombinant fragment (residues 242-443) contains the PAS 2 domain, enabling focused studies on dimerization, ligand binding, and structural aspects of circadian regulation without interf