BAX antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IP, IF, IHC, FC
  • 特异性:Human, Mouse, Rat; other species not tested.

产品详情

  • 产品名称
    BAX antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    BAX Rabbit Polyclonal antibody. Positive IP detected in Raji cells. Positive WB detected in HeLa cells, COLO 320 cells, HEK-293 cells, mouse kidney tissue, Raji cells, rat kidney tissue, RAW264.7 cells. Positive FC detected in Raji cells, HeLa cells. Positive IHC detected in human lymphoma tissue, human gliomas tissue, human testis tissue, mouse brain tissue. Positive IF detected in HEK-293 cells, HeLa cells. Observed molecular weight by Western-blot: 21-24 kDa
  • 抗体应用
    ELISA, WB, IP, IF, IHC, FC
  • 应用推荐

    Recommended Dilution:

    WB: 1:1000-1:10000

    IP: 1:1000-1:10000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • 特异性
    Human, Mouse, Rat; other species not tested.
  • 蛋白别名
    Apoptosis regulator BAX, BAX
  • 制备方法
    This antibody was obtained by immunization of BAX recombinant protein (Accession Number: NM_138761). Purification method: Protein A purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).
  • 参考文献
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