重组恒河猴BTLA蛋白

恒河猴

人胚胎肾细胞（HEK293）

Met 1 - Leu 155

A DNA sequence encoding the rhesus BTLA (EHH16054.1) (Met1-Leu155) was expressed with the Fc region of human IgG1 at the C-terminus.

> 90 % as determined by SDS-PAGE

Immobilized cynoBTLA-Fc at 10 μg/ml (100 μl/well) can bind biotinylated cynoTNFRSF14-Fc (Cat:504769), EC₅₀ of biotinylated cynoTNFRSF14-Fc (Cat:504769) is 0.7-1.64 μg/ml.

The recombinant rhesus BTLA comprises 366 amino acids and has a calculated molecular mass of 41.4 KDa.

A630002H24; CD272; B- AND T-LYMPHOCYTE-ASSOCIATED PROTEIN; B AND T LYMPHOCYTE ATTENUATOR; B- AND T-LYMPHOCYTE ATTENUATOR; BTLA1

B-and T-lymphocyte attenuator isoform 1

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.