Anti-STAT1 Rabbit antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:WB, IHC-P, ICC/IF, FC, IP
  • 特异性:Human

产品详情

  • 产品名称
    Anti-STAT1 Rabbit antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    STAT1 Rabbit polyclonal antibody
  • 抗体应用
    WB, IHC-P, ICC/IF, FC, IP
  • 应用推荐

    WB: 1/2000-1/10000

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/200-1/1000

    IP: 1/20

  • 特异性
    Human
  • 蛋白别名
    CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
  • 制备方法
    Antigen: A synthetic peptide of human STAT1
  • 组分
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • 储存方法
    Store at -20°C. Stable for 12 months from date of receipt.
  • 背景介绍
    Swiss-Prot Acc.P42224.Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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