Anti-SDC1 antibody

多克隆

兔

兔IgG

Rabbit Polyclonal to Human SDC1

WB, IP

Human Syndecan-1 / CD138 / SDC1

CD138, CD138, SDC1, Sstn, syndecan, Syndecan-1, Syndecan-1, SDC, CD138, SYND1, syndecan, Sstn, Synd, CD138, Synd1, syn-1, AA408134, AA409076, AA408134, AA409076, SDC, Sdc1, syn-1, Synd, Synd1, SYND1, syndecan

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human Syndecan-1 / CD138 / SDC1, and purified by antigen affinity chromatography.

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.