- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC-P
- 特异性:Mouse Prostasin / PRSS8
产品详情
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产品名称
Anti-Prostasin/PRSS8 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Rabbit polyclonal to Prostasin/PRSS8
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抗体应用
ELISA, WB, IHC-P
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应用推荐
WB: 10-20 μg/ml
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse Prostasin / PRSS8. The detection limit for Mouse Prostasin / PRSS8 is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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特异性
Mouse Prostasin / PRSS8
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蛋白别名
CAP1, PROSTASIN, fr, CAP1, mCAP1, C79772, AI313909, 2410039E18Rik, AI313909, C79772, CAP1, CAP1, mCAP12410039E18Rik, Prostasin, PROSTASIN, Prss8, PRSS8
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制备方法
Produced in rabbits immunized with purified, recombinant Mouse Prostasin / PRSS8 (rh Prostasin / PRSS8; EDL17608.1; Ala30-Gln289). Prostasin / PRSS8 specific IgG was purified by Mouse Prostasin / PRSS8 affinity chromatography.
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组分
0.2 μm filtered solution in PBS
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储存方法
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
背景介绍
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.