- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB
- 特异性:Human
产品详情
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产品名称
Anti-Phospho-IRE1 (Ser724) Rabbit antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Phospho-IRE1 (Ser724) Rabbit polyclonal antibody
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抗体应用
WB
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应用推荐
WB: 1/1000-1/5000
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特异性
Human
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蛋白别名
IRE1b; IRE2p; hIRE2p; IRE1-BETA
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制备方法
Antigen: A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1
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组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at -20°C. Stable for 12 months from date of receipt.
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背景介绍
Swiss-Prot Acc.O75460.Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).