Anti-Growth Hormone Receptor / GHR / GHBP antibody

多克隆

兔

兔IgG

Rabbit polyclonal to Growth Hormone Receptor / GHR / GHBP

ELISA, WB, IHC-P

Mouse Growth Hormone Receptor / GHR / GHBP

GHBP, GHIP, GHBP, GHR/BP, AA986417, GHBP, GHBP, Ghr, GHR, GHR/BP, Growth Hormone Receptor, Growth Hormone Receptor

Produced in rabbits immunized with purified, recombinant Mouse Growth Hormone Receptor / GHR / GHBP (rM Growth Hormone Receptor / GHR / GHBP; NP_034414.2; Met 1-Gln 273). Growth Hormone Receptor / GHR / GHBP specific IgG was purified by Mouse Growth Hormone Receptor / GHR / GHBP affinity chromatography.

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

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