Anti-Granzyme B/GZMB antibody

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  • 抗体类型:单克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, IHC-P
  • 特异性:Human Granzyme B / GZMB
    Has cross-reactivity in ELISA with Human Granzyme H

产品详情

  • 产品名称
    Anti-Granzyme B/GZMB antibody
  • 抗体类型
    单克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit monoclonal to Granzyme B/GZMB
  • 抗体应用
    ELISA, IHC-P
  • 应用推荐

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Granzyme B. The detection limit for Human Granzyme B is approximately 0.00975 ng/well.

    IHC-P: 0.5-5 μg/mL

  • 特异性
    Human Granzyme B / GZMB
    Has cross-reactivity in ELISA with Human Granzyme H
  • 蛋白别名
    CCP1, HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1, GZB, Ctla1, Ctla-1, AI553453, CCP-1/C11, AI553453, CCP1, CCP-1/C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, Ctla1, CTLA1, Ctla-1, CTSGL1, Gamb, Granzyme B, Granzyme B, GZB, GZMB, HLP, SECT
  • 制备方法
    This antibody was obtained from a rabbit immunized with purified, recombinant Human Granzyme B (rh Granzyme B; NP_004122.1; Met 1-Tyr 247)
  • 组分
    0.2 μm filtered solution in PBS with 5% trehalose
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
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