产品详情
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产品名称
Anti-FMC63 Monoclonal Antibody
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抗体类型
单克隆
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抗体亚型
Mouse IgG1, κ
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抗体应用
FC
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应用推荐
Flow Cytometry (Evaluation of Anti-CD19 (FMC63 scFv) CAR Expression).
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制备方法
Recombinant FMC63 scFv derived from HEK293 cells used as antigen.
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组分
PBS (pH7.4)
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储存方法
Store at -20℃. Avoid freeze / thaw cycles.
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抗体验证
Detection of FMC63-GFP Jurkat cells.
Flow cytometric analysis was conducted on Jurkat cells transfected with GFP-FMC63, with staining performed using anti-FMC63 antibody and isotype control.
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背景介绍
FMC63is a murine-derived scFv targeting a conserved CD19 epitope on B-cell malignancies, with high affinity and stability for robust tumor recognition. It serves as the antigen-sensing domain in FDA/EMA-approved CAR-T therapies (e.g., Kymriah®), enabling potent T-cell activation and cytotoxic killing of CD19+ cancer cells.