Anti-Ephrin-A1/EFNA1 antibody

0 条评论 | 添加你的评论
  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, IHC-P
  • 特异性:Human EphrinA1 / EFNA1

产品详情

  • 产品名称
    Anti-Ephrin-A1/EFNA1 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit polyclonal to Ephrin-A1/EFNA1
  • 抗体应用
    ELISA, IHC-P
  • 应用推荐

    ELISA: 0.5-1.0 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human EFNA1. The detection limit for Human EFNA1 is 0.00245 ng/well.

    IHC-P: 0.1-2 μg/mL

  • 特异性
    Human EphrinA1 / EFNA1
  • 蛋白别名
    B61, EFL1, ECKLG, EPLG1, LERK1, LERK-1, TNFAIP4, B61, Efl1, Epl1, Eplg1, Lerk1, AI325262, AI325262, B61, B61, ECKLG, Efl1, EFL1, Efna1, EFNA1, Ephrin A1, Ephrin-A1, Epl1, Eplg1, EPLG1, Lerk1, LERK1, TNFAIP4
  • 制备方法
    Produced in rabbits immunized with purified, recombinant Human EphrinA1 / EFNA1 (rh EphrinA1; NP_004419.2; Met 1-Ser182). EphrinA1 specific IgG was purified by human EphrinA1 affinity chromatography.
  • 组分
    0.2 μm filtered solution in PBS with 5% trehalose
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.
  • 参考文献
    • Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
    • Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
    • Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！