Anti-CNDP2 antibody

0 条评论 | 添加你的评论
  • 抗体类型:单克隆
  • 抗体来源:兔
  • 抗体应用:IHC-P
  • 特异性:Mouse CNDP2
    Has cross-reactivity in ELISA with Human CNDP2

产品详情

  • 产品名称
    Anti-CNDP2 antibody
  • 抗体类型
    单克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit monoclonal to CNDP2
  • 抗体应用
    IHC-P
  • 应用推荐

    IHC-P: 1-10 μg/mL

  • 特异性
    Mouse CNDP2
    Has cross-reactivity in ELISA with Human CNDP2
  • 蛋白别名
    0610010E05Rik, C76600, Cn2, CN2, Cndp2, CNDP2, CPGL, Dip-2, FLJ10830, HsT2298, Pep1, Pep-1, PEPA, CN2, CPGL, PEPA, HsT2298, HEL-S-13, Cn2, Pep1, Dip-2, Pep-1, C76600, 0610010E05Rik
  • 制备方法
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; NP_075638.2; Met1-Asn475).
  • 组分
    0.2 μm filtered solution in PBS with 5% trehalose
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    Mouse cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
  • 参考文献
    • Bakker,SJ. et al., 2008, Diabetes  57 (12):e16; author reply e17. 
    • Wanic, K. et al., 2008, Diabetes  57 (9): 2547-51.
    • McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
    • Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！