Anti-ANP32A antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:WB, ELISA, IHC-P, ICC/IF, IF, IP
  • 特异性:Human ANP32A / PHAP1

产品详情

  • 产品名称
    Anti-ANP32A antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit Polyclonal to Human ANP32A
  • 抗体应用
    WB, ELISA, IHC-P, ICC/IF, IF, IP
  • 应用推荐

    WB: 1-5 μg/ml

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ANP32A / PHAP1.

    IHC-P: 0.1-2μg/mL

    ICC/IF: 0.5-3μg/mL

    IP: 1-4 uL/mg of lysate

  • 特异性
    Human ANP32A / PHAP1
  • 蛋白别名
    LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, pp32, Anp32, PHAP1, I1PP2A, W91701, Anp32, Anp32a, I1PP2A, I1PP2A, LANP, LANP, MAPM, MGC119787, PHAPI, pp32, PP32, W91701, ANP32A, C15orf1, MGC150373, PHAP1, PHAP1
  • 制备方法
    Produced in rabbits immunized with purified, recombinant Human ANP32A / PHAP1 . ANP32A / PHAP1 specific IgG was purified by Human ANP32A / PHAP1 affinity chromatography.
  • 组分
    0.2 μm filtered solution in PBS
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    acidic leucine-rich nuclear phosphoprotein 32 family member A, also known as acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI and ANP32A, is a nucleus, cytoplasm and endoplasmic reticulum. ANP32A / LANP is expressed in all tissues tested. It is highly expressed in kidney and skeletal muscle, moderate levels of expression is in brain, placenta and pancreas. ANP32A / LANP is weakly expressed in lung. It is found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. ANP32A / LANP is a component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. It directly interacts with SET. ANP32A / LANP also interacts with ATXN1/SCA1. ANP32A / LANP is implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. ANP32A / LANP plays a role in E4F1-mediated transcriptional repression.

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