- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB
- 特异性:Cynomolgus ALK-1 / ACVRL1
产品详情
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产品名称
Anti-ALK-1 / ACVRL1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Rabbit polyclonal to ALK-1 / ACVRL1
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抗体应用
ELISA, WB
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应用推荐
WB: 5-20 μg/ml
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Cynomolgus ALK-1 / ACVRL1.
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特异性
Cynomolgus ALK-1 / ACVRL1
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蛋白别名
ACVRL1, ACVRL1, ACVRL1, ACVRLK1, ACVRLK1, AI115505, AI427544, ALK1, ALK1, ALK-1, ALK-1, HHT, HHT2, MGC91691, ORW2, R3, R-3, SETHKIR, SKR3, TSR-I, HHT, ALK1, HHT2, ORW2, SKR3, ALK-1, TSR-I, ACVRLK1, Alk1, Acvrlk1, AI115505, AI427544
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制备方法
Produced in rabbits immunized with purified, recombinant Cynomolgus ALK-1 / ACVRL1 (XP_005570958.1; Met1-Gln118). ALK-1 / ACVRL1 specific IgG was purified by Cynomolgus ALK-1 / ACVRL1 affinity chromatography.
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组分
0.2 μm filtered solution in PBS
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储存方法
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
背景介绍
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
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参考文献
- French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
- Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
- Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.