Recombinant Alpha-hemoglobin-stabilizing protein (AHSP) fragment (residues 1-102) from Homo sapiens, engineered to provide a stable and soluble unit ideal for structural and biochemical studies. This fragment captures the essential chaperone activity of AHSP, supporting research into hemoglobin stability and erythroid cell development.

Alpha-hemoglobin-stabilizing protein (AHSP), also known as Erythroid differentiation-related factor, functions as a critical chaperone in erythroid cells. It specifically prevents the aggregation of free alpha-hemoglobin during normal development, thereby protecting cells from harmful precipitation. AHSP is localized in the cytoplasm and is implicated in modulating pathological conditions such as beta-thalassemia, where excess alpha-hemoglobin occurs. This recombinant fragment (1-102) represents a stable, soluble domain selected for its suitability in experimental analyses, enabling deeper insights into AHSP's protective mechanisms and therapeutic potential.