Recombinant Acetylcholine receptor subunit beta (CHRNB1) fragment (residues 24-244) from Homo sapiens, designed for structural and biochemical studies. This 221-amino acid soluble fragment retains key features for investigating acetylcholine-mediated signaling pathways.

The full-length Acetylcholine receptor subunit beta (CHRNB1) functions as a ligand-gated ion channel that undergoes extensive conformational changes upon acetylcholine binding, leading to opening of an ion-conducting channel across the plasma membrane (PubMed:27375219). Located in the postsynaptic cell membrane as a multi-pass membrane protein, it plays a critical role in neurotransmission and synaptic signaling. The selected fragment (24-244) represents a stable, soluble unit optimized for experimental applications while maintaining relevance to the native protein's functional architecture.