Pyr-GCCNGPKGCSSKWCRDHARCC-NH2 (disulfide bond Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22)
长度 (aa)
22
多肽纯度 (HPLC)
95.14
分子式
C92H141N35O28S6
分子量
2375.8
来源
固相合成
描述
µ-Conotoxins are small, potent, peptide voltage-gated sodium (NaV) channel inhibitors characterised by a conserved cysteine framework.
NaV channels are key players in the generation and propagation of action potentials, and selective blockade of these channels is a promising strategy for clinically useful suppression of electrical activity. The conotoxin m-CnIIIC from the cone snail Conus consors exhibits myorelaxing activity in rodents through specific blockade of skeletal muscle (NaV1.4) NaV channels.