重组大鼠GGT1蛋白

大鼠

人胚胎肾细胞（HEK293）

Pro 27 - Tyr 568

A DNA sequence encoding the rat GGT1 (P07314) (Pro27-Tyr568) was expressed, fused with a polyhistidine tag at the N-terminus.

> 70 % as determined by SDS-PAGE

The recombinant rat GGT1 comprises 562 amino acids and has a predicted molecular mass of 61.1 kDa. The apparent molecular mass of the protein is approximately 54-57 kDa in SDS-PAGE under reducing conditions.

GGT; DWG; GAMMA-GLUTAMYLTRANSPEPTIDASE 1; GGT 1; GGTP; GTG; LEUKOTRIENE-C4 HYDROLASE; D22S672; GGT1; GLUTATHIONE HYDROLASE 1; CD224; GAMMA-GLUTAMYL TRANSPEPTIDASE; GGT-1; D22S732; GLUTAMYL TRANSPEPTIDASE

Gamma-glutamyltranspeptidase 1

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism (By similarity).

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.